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"Balance...a medication that works for you, a support system and a doctor you trust."

Injections

Rebif® (interferon beta-1a ) is available in ready-to-use pre-filled syringes, so you don't ever have to worry about mixing any solutions before injecting. And Rebif uses a 29-gauge needle – the thinnest needle of any MS therapy. When you fill a prescription for Rebif you will receive a month's supply of syringes (12 syringes for 3 injections a week for 4 weeks). No extra syringes, needles, or other materials are needed and no needle assembly is required.

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Rebiject II(R) autoinjector

Design for convenience and ease of use.

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You inject Rebif just three times a week

You can pick the days that work best with your schedule. For example, you might choose a Monday, Wednesday, Friday schedule - and leave your weekends free from injections. Whichever days you choose, your injections should be at least two days (48 hours) apart.

If you miss a dose of Rebif, take your next dose as soon as you remember and skip the following day.

Be sure to take the dose prescribed by your doctor. Do not change your dose without talking to your doctor. If you accidentally take more than your prescribed dose, call your doctor right away.

You can use the pre-measured, pre-filled syringes as-is, or with the Rebiject II® autoinjector designed for use only with Rebif. Using Rebiject II may help make your injections easier to manage. To find out more about Rebiject II and how you can receive it free, click here.

Learning to inject Rebif

Do not try to inject Rebif before you are properly trained to do so. It is important that you or your care partner understand and are comfortable with giving injections. Your health care provider may teach you and/or your care partner the proper way to inject Rebif. Your doctor may also refer you to an MS LifeLines® Support Program specialist who will arrange for a health care professional to visit your home, at no charge, to provide instruction. You can also call one of our MS LifeLines specialists toll free at 1-877-447-3243 Monday through Friday, 8 a.m. to 8 p.m. ET.

It's understandable to feel apprehensive about administering injections yourself to treat your relapsing MS. We hope this video will give you the information you need.

Brought to you by EMD Serono, Inc. and Pfizer Inc., the co-marketers of Rebif® (interferon beta-1a) in the US EMD SeronoPfizer

Prescribing Information - Medication Guide

This information is intended only for residents of the United States.

Rebif is used to treat relapsing forms of MS to decrease the frequency of relapses and delay the occurrence of some of the physical disability that is common in people with MS. Efficacy has been established in controlled studies up to 2 years in duration. Rebif is not approved for the treatment of chronic progressive multiple sclerosis. Rebif is available by prescription only in 22 mcg and 44 mcg pre-filled syringes and a titration pack.

Before beginning treatment, patients should discuss with their doctor the potential benefits and risks associated with Rebif. Let your doctor know if you have a history of depression, seizures, liver disease, thyroid problems, and blood count or bleeding problems or if you have had previous allergic reactions to medications. Tell your doctor about all medicines you take, including prescription and non-prescription medicines, vitamins and herbal supplements. Rebif and other medicines may affect each other causing serious side effects. Talk to your doctor before you take any new medicines. Rebif is not recommended for women who are or plan to become pregnant.

Potential serious side effects of Rebif include depression, liver problems, risk to pregnancy, injection site problems and severe allergic reactions. Allergic reactions are rare and may be associated with difficulty breathing and loss of consciousness, which requires immediate medical attention.

The most common side effects with Rebif are injection site reactions, flu-like symptoms (fever, chills, muscle aches, tiredness), depression, abdominal pain, increased liver enzymes, and blood cell count decreases. Let your doctor know immediately if you have any of these symptoms or feel sad, tired, hot or cold, experience hives, rashes, bruising, yellowing of the skin, or a change in body weight (gain or loss).

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

This information is not intended to replace discussions with your healthcare provider. For additional information about Rebif, please consult the Medication Guide or Prescribing Information and talk to your doctor. You can also call toll free 1-877-44-REBIF (1-877-447-3243). Rebif is available by prescription only.

MS LifeLines is an educational support service for people living with MS and their families. MS LifeLines and MS LifeLines Ambassadors are sponsored by EMD Serono, Inc. and Pfizer Inc.

Rebif, Rebiject II and MS LifeLines are registered trademarks and the Rebif logo is a trademark of EMD Serono, Inc. or its affiliates.

MS in Balance is a service mark of EMD Serono, Inc. or its affiliates.

Copyright 2008 EMD Serono, Inc. All rights reserved.